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GLP1-R agonists have been shown to provide anti-inflammatory and endothelial protective benefits through the activation of peroxisome proliferator-activated receptor (PPAR)

The authors recommend weight-based (lean body weight) dose calculation, reducing concentration as volume increases, incremental injection with aspiration, close post-block monitoring, and routine consideration of low-dose epinephrine to blunt peak plasma levels

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Alcohol consumption can affect glycemic control, and the combination of GLP-1 therapy with alcohol might increase hypoglycemia risk, particularly in patients taking concomitant insulin or sulfonylureas